Androgenic directed compositions

Details Androgenic directed compositions Androgenic directed compositions

C - Chemistry, Metallurgy

07

D

C07D 233/72 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/555 (2006.01) A61K 31/70 (2006.01) A61K 38/05 (2006.01) A61K 49/04 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07D 233/74 (2006.01) C07D 233/84 (2006.01) C07D 233/86 (2006.01) C07D 233/88 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 413/06 (2006.01) C07D 475/08 (2006.01) C07F 7/22 (2006.01) C07H 15/252 (2006.01) C07K 5/062 (2006.01) C07K 9/00 (2006.01)

Patent

CA 2225484

Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targeting to the endrogenic receptor containing cells of cytostatic and/or cytotoxic agents, heavy or light radioactive or radioopaque atoms, and the like for detection and treatment of cancer cells involving androgenic receptors or blocking androgenic receptors.

L'invention porte sur des phénylthiohydantoïnes substituées, utilisées pour déceler la présence de cellules tumorales possédant des récepteurs androgènes et également utilisées pour leur action cytostatique et cytotoxique sur ces cellules. Les composés selon l'invention procurent des véhicules destinés à un ciblage spécifique des cellules contenant un récepteur androgène, d'agents cytostatiques et/ou cytotoxiques, des atomes à radioactivité élevée ou faible ou bien opaques aux rayons X, etc., aux fins de la détection et du traitement de cellules cancéreuses faisant intervenir des récepteurs androgènes ou bloquant des récepteurs androgènes.

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