Androst-4-eno¬4,5-b|pyrrole derivatives and process for...

Details Androst-4-eno¬4,5-b|pyrrole derivatives and process for... Androst-4-eno¬4,5-b|pyrrole derivatives and process for...

C - Chemistry, Metallurgy

07

J

C07J 71/00 (2006.01) A61K 31/58 (2006.01) C07J 7/00 (2006.01)

Patent

CA 2120726

2120726 9404554 PCTABS00030 This invention provides compounds of formula (I), wherein x, y, z represent single or double bonds; R is hydrogen or C1-C4 alkyl; R1 is hydrogen or an acyl group; R2 is hydrogen; C1-C4 alkyl unsubstituted or substituted by phenyl; phenyl unsubstituted or substituted by C1-C4 alkyl or C1-C4 alkoxy; and A is a >C=O, >CH OH or >CH OR3 group, in which R3 is an acyl group provided that one of z and y is a double bond and the other is a single bond. The compounds are useful as aromatase inhibitors.

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