C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/15, 260/59
C07J 1/00 (2006.01) C07J 3/00 (2006.01) C07J 21/00 (2006.01)
Patent
CA 1084483
Abstract of the Disclosure The invention provides novel esters of androstadiene 17-carboxylic acids of the formula Image (I) wherein R' represents a free hydroxyl group or a hydroxyl group which is esterified with a carboxylic acid having not more than 7 carbon atoms, R" represents a methyl group in the .alpha.- or .beta.-position or the methylene group, and R' and R" together represent the 16.alpha.,17.alpha.-dihydroxyacetonide group Image wherein R is H or C1, each of X and Y represents a hydrogen, chlorine or fluorine atom, with the proviso that at least one of these substituents is one of these halogens, when R is C1, and that Y is only C1 of F and X only H or C1, when R is H and that the androstadiene-17-carboxylic acid does not contain more than 11 carbon atoms. The new esters have pronounced antiinflammatory action. On local application side-effects on thymus, adrenals and body weight can only be observed at doses remarkably higher than the therapeutic doses. They can be used in dermatology. - 1b -
272291
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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