Androstane derivatives, processes for their manufacture and...

Details Androstane derivatives, processes for their manufacture and... Androstane derivatives, processes for their manufacture and...

C - Chemistry, Metallurgy

07

J

260/36

C07J 1/00 (2006.01) C07J 21/00 (2006.01) C07J 53/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1210754

ABSTRACT Novel androstane derivatives, processes for their manufacture and their use as medicaments Novel androstane derivatives of the general formula I Image (I) (in which Image represents a single or double bond, R1 represents methyl or ethyl, R2 represents H or C1-C8- alkyl, X represents -(CH2)n-, -CE=CH-(CH2)m- or -C?C-(CH2)m-, n representing 2 to 6 and m representing 1 to 4, -A-B- represents -CH2-CH2-, -CH=CH-, -CCl-CH-, Image Image or Image with the exception of 17.alpha.-(3- acetoxypropyl)-17.beta.-hydroxy-.DELTA.4,6-androstadien-3-one) and processes for their manufacture. The novel compounds are pharmacologically active substances distinguished, especially on topical application, by a sebum-suppressive activity, and may accordingly be made up with suitable carriers into pharmaceutical pre- parations.

408184

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