Androstane steroids as neurochemical initiators of change in...

C - Chemistry – Metallurgy – 07 – J

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C07J 13/00 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) C07J 1/00 (2006.01) C07J 3/00 (2006.01)

Patent

CA 2165325

The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administered a human semiochemical, e.g. an Androstane steroid, or a pharmaceutical composition containing a semiochemical, such that the ligand semiochemical binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or mole pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

L'invention concerne un procédé de modification de la fonction hypothalamique chez un individu. Ledit procédé consiste à administrer par voie nasale un produit écomone humain tel qu'un stéroïde d'androstane, ou une composition pharmaceutique contenant un produit écomone, de sorte que le produit écomone ligand se lie à un récepteur neuroépithélial spécifique. Le ou les stéroïdes sont, de préférence, administrés sous forme de composition pharmaceutique contenant un ou plusieurs excipients pharmaceutiquement acceptables. L'invention porte également sur des compositions pharmaceutiques contenant lesdits stéroïdes.

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