Androstene-17-dithioketals

Details Androstene-17-dithioketals Androstene-17-dithioketals

C - Chemistry, Metallurgy

07

J

260/28.4

C07J 31/00 (2006.01) C07J 1/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 1205463

ABSTRACT ANDROSTENE-17-DITHIOKETALS Topical antiinflammatory activity is exhibited by steroids having the formula Image and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the oth.er is alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, mono-, di- or trifluoroalkyl; cyanoalkyl, alkanoylalkyl or Image wherein n is 1, 2, 3 or 4 and Y1 and Y2 are the same or different and each is hydrogen or alkyl; R3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy,or fluorine; R4 is carbonyl, .beta.-hydroxymethylene or .beta.-acetyloxymethylene; R5 is hydrogen or halogen; and R6 is hydrogen, methyl, hydroxy, alkanoyl, alkanoyloxy or halogen.

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