Androsterone derivatives for inhibiting dna binding of ap-1...

Details Androsterone derivatives for inhibiting dna binding of ap-1... Androsterone derivatives for inhibiting dna binding of ap-1...

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/566 (2006.01) A61K 31/5685 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 43/00 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2260584

There is provided a method for the use of the adrenal steroid dehydroepiandrosterone and certain of its analogs to reduce growth of immortalized and malignant cell lines. Dehydroepiandrosterone and its potent analogs 16.alpha.-bromo-5-androsten-17-one, 16.beta.-bromo- 5-androsten-17-one, 16.alpha.-fluoro-5-androsten-17-one, 16.beta.- fluoro-5-androsten-17-one, 16.alpha.-bromo-5-androstan-17- one, 16.beta.-bromo-5-androstan-17-one, 16.alpha.-fluoro-5- androstan-17-one, and 16.beta.-fluoro-5-androstan-17-one impair activation of secondary growth response genes and thus prove useful for treatment of asthmatic airway remodellina in man.

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