Anellated dihydropyridines and the use thereof for preparing...

Details Anellated dihydropyridines and the use thereof for preparing... Anellated dihydropyridines and the use thereof for preparing...

C - Chemistry, Metallurgy

07

D

C07D 217/14 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 217/16 (2006.01) C07D 217/18 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01) C07D 491/056 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2178209

A compound of the general formula (I) in which A is a benzo, indolo or thieno radical, B is the group -0-, -S- or -CHR5-, in which R5 is hydrogen, (C1-C6) alkyl, phenyl or benzyl, R3 is 2- or 3-thienyl, (C4-C7) cycloalkyl, (C4-C6) cycloalkyl (C1-C5) alkyl or (1) or (2) in which R is (C1-C4) alkyl, hydroxy, - N3, halogen (F, C1, Br, I), CF3 or (C1-C4) alkoxy, u is 0, 1, 2 or 3, and m, R2, R4, R7, R8 and R9 are as defined in the description, and pharmaceutical preparations containing this compound and their pharmaceutical use.

L'invention concerne un composé de la formule générale (I) dans laquelle A désigne un reste benzo, indolo ou thiéno; B désigne le groupe -O-, -S- ou CHR?5¿-, R?5¿ désignant hydrogène, alkyle (C¿1?-C¿6?), phényle ou benzyle; R?3¿ désigne thiényl-2 ou -3, cycloalkyle (C¿4?-C¿7?), cycloalkyle (C¿4?-C¿6?) alkyle C¿1?-C¿5? ou (1) ou (2) où R désigne alkyle C¿1?-C¿4?, hydroxy, -N¿3?, halogène (F, Cl, Br, I), CF¿3? ou alcoxy C¿1?-C¿4?, u vaut 0, 1, 2 ou 3, et m, R?2¿, R?4¿, R?7¿, R?8¿ et R?9¿ ont la notation mentionnée dans la description. L'invention concerne par ailleurs des préparations pharmaceutiques contenant ces composés et leur utilisation à des fins pharmaceutiques.

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