Anellated indole derivatives

Details Anellated indole derivatives Anellated indole derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/299

C07D 471/04 (2006.01) C07D 471/06 (2006.01) C07D 487/04 (2006.01) C07D 487/06 (2006.01) C07D 498/04 (2006.01) C07D 498/06 (2006.01) C07D 513/06 (2006.01)

Patent

CA 1314879

DIR 0396 ABSTRACT: The invention relates to new anellated indole derivatives of general formula 2, Image (2) wherein - R0 is alkyl or alkoxy having 1-4 C-atoms, phenylalkoxy having 1-3 C-atoms in the alkoxy group, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or a group R7S(O)p, wherein R7 is alkyl having 1-4 C-atoms and p has the value 0, 1 or 2, or R0 is a group R8R9N, R8R9N-CO-CH2- or R8R9-N-C0 wherein R8 and R9 are hydrogen or alkyl having 1-4 C-atoms or R8R9N forms a saturated 5- or 6-ring and n has the value 0, l or 2, Z together with the carbon atom and nitrogen atom to which Z is bound and the intermediate carbon atom, forms a heterocyclic group consisting of 5-8 ring atoms, in which, in addition to the nitrogen atom already present, a -CO-group or a second hetero atom from the group N, 0, S, S-O or SO2 may be present, which ring may be substitu- ted with 1-3 alkyl groups having 1-4 C-atoms, a phenyl group or a spiroalkyl group (C2-C5), or which ring may be anellated with a saturated or non-saturated carbocyclic or heterocyclic ring which consists of 5- or 6-ring atoms and which may be substituted with halogen, alkyl or alkoxy having 1-4 C-atoms, and m has the values 1-5, - one of the groups R2, R3 and R4 is hydrogen, alkyl having DIR 0396 1-6 C-atoms, cycloalkyl having 3-7 C-atoms, alkenyl having 2-6 C-atoms or phenylalkyl having 1-3 C-atoms in the alkyl group, and the two other groups independently of each other are hydrogen or alkyl having 1-6 C-atoms, and the pharmaceutically acceptable acid addition salts thereof. These compounds are strong and selective antago- nists of "neuronal" 5-hydroxytryptamine (5-HT) receptors, and have a considerably longer-lasting effect and lower toxicity in comparison with related known compounds.

570420

Affiliated with

Also associated with

Rating

Anellated indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anellated indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anellated indole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1274313