Anethole dithiolethione and other dithiolethiones for the...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 339/04 (2006.01) A61K 31/385 (2006.01)

Patent

CA 2594165

The invention relates to dithiolethiones derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment, amelioration or prevention of conditions associated with dysfunction of monoamine neurotransmission. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

L'invention concerne des dérivés de dithioléthiones utilisés comme inhibiteurs de la monoamine-oxydase, notamment des inhibiteurs MAO-B, des procédés de préparation de ces composés et des intermédiaires utiles dans la synthèse des dérivés de dithioléthiones. L'invention concerne également l'utilisation d'un composé dans la fabrication d'un médicament conférant un effet bénéfique. Dans des modes de réalisation, l'invention concerne des composés spécifiques, lesquels sont utilisés pour la fabrication d'un médicament utile dans le traitement, l'amélioration ou la prévention d'états associés au dysfonctionnement de la neurotransmission par la monoamine. Les composés sont de formule générale (1) dans laquelle les symboles ont les significations présentées dans la description.

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