C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) G01N 33/566 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2546406
The present invention relates to angiogenesis inhibiting molecules that are the monoclonal antibody H33 or fragments or derivatives thereof, to their use in the treatment of cancer, in particular the treatment of solid tumors and to therapeutical and diagnostic compositions comprising them. The invention relates in particular to humanized derivatives of H33 or human monoclonal antibodies having the specificity of H33.
La présente invention concerne des molécules inhibitrices d'angiogenèse qui sont des anticorps H33 monoclonaux, des fragments ou des dérivés de ceux-ci, leur utilisation dans le traitement du cancer, en particulier le traitement de tumeurs solides, des compositions thérapeutiques et diagnostiques comprenant ces molécules. Cette invention concerne aussi des dérivés humanisés de H33 ou des anticorps monoclonaux humains possédant la spécificité de H33.
Aurrand-Lions Michel
Imhof Beat A.
Fetherstonhaugh & Co.
Laboratoires Serono S.a.
Merck Serono Sa
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