Angiogenesis inhibition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/728 (2006.01) A61K 31/00 (2006.01) A61K 31/18 (2006.01) A61K 31/715 (2006.01) A61K 31/717 (2006.01) A61K 31/718 (2006.01) A61K 31/727 (2006.01) A61K 31/737 (2006.01) A61K 45/06 (2006.01) A61P 29/02 (2006.01) A61P 35/00 (2006.01) A61P 41/00 (2006.01) A61K 9/70 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2365767

Angiogenesis is inhibited by the local administration of a pharmaceutical preparation formed from the reaction of hyaluronic acid, carboxymethylcellulose and a carbodiimide. The preparation, which can be in the form of a film or a gel, is advantageously applied directly to the site of a tumor, such as a cancerous tumor, used in conjunction with other chemotherapeutic techniques, or used to treat a chronic inflammatory condition, such as rheumatoid arthritis, endometriosis, arteriosclerosis, intimal hyperplasia, proliferative retinopathy, and the like.

L'invention concerne l'inhibition d'une angiogenèse par administration locale d'une préparation pharmaceutique formée par mise en réaction d'acide hyaluronique, de carboxyméthylcellulose et d'un carbodiimide. La préparation, qui peut être sous forme de film ou de gel, s'applique avantageusement directement sur le site d'une tumeur, telle qu'une tumeur cancéreuse, ou s'utilise conjointement avec d'autres techniques thérapeutiques, ou encore s'utilise pour le traitement d'une affection inflammatoire chronique telle que l'arthrite rhumatoïde, l'endométriose, l'artériosclérose, l'hyperplasie, la rétinopathie proliférante, et analogues.

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