Angiogenesis inhibitor

A - Human Necessities – 61 – K

Patent

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167/103.9

A61K 38/18 (2006.01) C07K 14/375 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1336817

The present invention discloses an angiogenesis inhibitor containing as an active ingredient protein-polysaccharides produced by extraction of mycelia or fruit bodies obtained from culture of a Basidiomycete belonging to a genus Coriolus. The protein-polysaccharide contains about 18 to about 38% by weight of protein, being free from protein-polysaccharides having molecular weight of lessthan 5,000. More in detail, said protein-polysaccharides of the present invention contains 3 to 6% of nitrogen, a polysaccharide portion thereof, as the main fraction, is composed of .beta.-D-glucan and this glucan portion has branched structures containing 1?3, 1?4 and 1?6 bonds, wherein the protein- component amino acids are mostly acidic arnino acids of aspartic acid and glutamic acid, and neutral amino acids of valine and leucine, while the basic amino acids of lysine and alginine are small in content, and the protein- polysaccharide is soluble in water but hardly soluble in methanol, pyridine, chloroform, benzene and hexane and starts to be gradually decomposed at about 120°C.

603576

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