A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/435 (2006.01) C07C 235/52 (2006.01) C07C 247/04 (2006.01) C07C 271/22 (2006.01) C07C 279/08 (2006.01) C07C 311/19 (2006.01) C07D 233/48 (2006.01) C07D 235/14 (2006.01) C07D 235/30 (2006.01) C07D 295/215 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2336774
RGD mimetics which combine a nitroaryl moiety with an arylether/.alpha.- aminoacid/guanidine framework exhibit activity as antagonists toward various integrins and as inhibitors of angiogenesis.
L'invention porte sur des mimétiques RGD qui combinent une fraction nitroaryle avec une structure aryléther/.alpha.-aminoacide/guanidine et présentent une activité faisant intervenir des antagonistes vis à vis de diverses intégrines et des inhibiteurs de l'angiogenèse.
Chibale Kelly
Goodman Simon
Jandeleit Bernd
Nicolaou Kyriacos C.
Trujillo John
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
The Scripps Research Institute
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