Angiogenesis inhibitors

Details Angiogenesis inhibitors Angiogenesis inhibitors

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/695 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2611391

The present invention relates to the use of compounds for the treatment of angiogenesis related disorders involving a protein kinase as a medicament. The compounds e.g. have the general formula I. In preferred embodiments Rl and R5 are independently selected from hydrogen, halogen, cyano, nitro, CF3 and methyl, R2 and R4 are independently selected from hydrogen, alkyl and NHR7, wherein R7 is optionally substituted aryl, and R3 is optionally substituted C1- C6 alkyl, optionally substituted aryl or optionally substituted 5-or 6- membered heterocycle.

Utilisation de composés pour le traitement des troubles liés à l'angiogenèse faisant intervenir comme médicament une protéine kinase. Les composés sont par exemple de formule générale I. En modes de réalisation préférés, Rl et R5 sont indépendamment hydrogène, halogène, cyano, nitro, CF3 et méthyle, R2 et R4 sont indépendamment hydrogène, alkyle et NHR7, tandis que R7 est aryle éventuellement substitué et que R3 est C1-C6 alkyle éventuellement substitué, aryle éventuellement substitué ou un hétérocycle à 5 ou 6 éléments éventuellement substitué.

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