Angiogenesis inhibitors

Details Angiogenesis inhibitors Angiogenesis inhibitors

C - Chemistry, Metallurgy

07

C

C07C 251/54 (2006.01) A61K 31/195 (2006.01) A61K 31/421 (2006.01) A61P 9/10 (2006.01) A61P 27/14 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 251/24 (2006.01) C07D 263/32 (2006.01)

Patent

CA 2403903

Neovascularization inhibitors containing compounds of the general formula (II) or salts thereof are useful as preventive and therapeutic drugs for tumors and so on, wherein R4 is an optionally substituted hydrocarbon group or the like; Xa is a free valency or the like; k is an integer of 1 to 3; Ya is oxygen or the like; ring Ea is a benzene ring which may have an additional substituent; p is an integer of 1 to 8; R5 is hydrogen or the like; q is an integer of 0 to 6; r is 0 or 1; R8 is hydroxyl or the like; and R6 and R7 are each hydrogen or the like.

L'invention porte sur des inhibiteurs de la néovascularisation contenant des composés de formule générale (II) ou leurs sels utilisables comme médicaments préventifs et curatifs des tumeurs. Dans ladite formule: R?4¿ est un groupe hydrocarbure facultativement substitué ou analogue; Xa est une valence libre ou analogue; k est un entier de 1 à 3; Ya est oxygène ou analogue; le cycle Ea est un cycle benzène ou analogue pouvant présenter un substituant additionnel; p est un entier de 1 à 8; R?5¿ est H ou analogue; q est un entier de 0 à 6; r est 0 ou 1; R?8¿ est hydroxyle ou analogue; et R?6¿ et R?7¿ sont chacun H ou analogue.

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