Angiogenesis inhibitors

Details Angiogenesis inhibitors Angiogenesis inhibitors

A - Human Necessities

61

K

A61K 31/416 (2006.01) A61K 31/00 (2006.01) A61K 31/4745 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2478918

A method for treating an angiogenesis-related disorder. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula (I): Each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R1, R2, R3, R4, R5, and R6, independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR', (CH2)mOR, (CH2)mSR, (CH2)mNRR', (CH2)mCN, (CH2)mC(O)OR, (CH2)mCHO, (CH2)mCH=NOR, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are O(CH2)mO, in which each of R and R', independently, is H or C1.sim.C6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.

L'invention porte sur un procédé de traitement d'une maladie relative à l'angiogenèse. Ce procédé consiste à administrer à un sujet une quantité effective d'un composé de formule (I): chacun de Ar¿1?, Ar¿2? et Ar¿3?, indépendamment, représente phényle, thiényle, furyle, pyrrolyle, pyridinyle ou pyrimidinyle; chacun de R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6?, indépendamment, représente R, nitro, halogène, C(O)OR, C(O)SR, C(O)NRR', (CH¿2?)¿m?OR, (CH¿2?)¿m?SR, (CH¿2?)¿m?NRR', (CH¿2?)¿m?CN, (CH¿2?)¿m?C(O)OR, (CH¿2?)¿m?CHO, (CH¿2?)¿m?CH=NOR, ou bien R¿1? et R¿2? réunis, R¿3? et R¿4 ?réunis ou R¿5? et R¿6 ?réunis représentent O(CH¿2?)¿m?O, chacun de R et R', indépendamment, représentant H ou C¿1?~C¿6? alkyle; et m représente 0, 1, 2, 3, 4, 5 ou 6 et n représente 0, 1, 2, or 3.

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