C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/78 (2006.01) A61P 35/04 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2432932
This invention pertains to methods and compositions for inhibiting endothelial cell tube formation, the initial step of tumor angiogenesis. More specifically, the present invention relates to tripeptides that show inhibition of angiogenesis-mediated processes. The most preferred amino acid sequences are SNS and SQS.
L'invention porte sur des procédés et des compositions inhibant la formation de tubules de cellules endothéliales, premier stade de l'angiogenèse de tumeurs. L'invention porte plus spécialement sur des tripeptides s'étant montré des inhibiteurs de processus médiés par l'angiogenèse. Les séquences d'acides aminés ayant la plus grande préférence sont SNS et SQS.
Mousa Shaker A.
Scialdone Mark A.
Shuey Steven W.
Bennett Jones Llp
E. I. Du Pont de Nemours And Company
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