Angiogenesis regulator genes, pharmaceutical preparations...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2478839

The invention concerns therapeutic compositions in the field of angiogenesis, comprising nucleotide sequences of genes whereof the involvement in the mechanism of angiogenesis has been demonstrated including their complementary sequences, their antisense sequences, polypeptide sequences encoded by the encoding parts of said genes as well as antibodies directed against said polypeptide sequences. The invention also concerns genetically modified cells underexpressing or overexpressing said genes, therapeutic compositions containing them, for use in treating angiogenic disorders. The invention further concerns methods for diagnosis and/or prognosis of angiogenic disorders as well as novel methods for screening compounds active in the treatment of said disorders.

L'invention se rapporte à des compositions thérapeutiques dans le domaine de l'angiogenèse, comportant des séquences nucléotidiques de gènes dont on a mis en évidence leur implication dans le mécanisme de l'angiogénèse y compris leurs séquences complémentaires, les séquences antisens, des séquences polypeptidiques codées par les parties codantes desdits gènes ainsi que des anticorps dirigés contre lesdites séquences polypeptidiques. L'invention concerne aussi des cellules génétiquement modifiées sous-exprimant ou surexprimant lesdits gènes, des compositions thérapeutiques les contenants, utiles pour le traitement de désordres angiogéniques. L'invention concerne également des méthodes de diagnostic et/ou pronostic de désordres angiogéniques ainsi que des nouvelles méthodes de criblage des composés actifs dans le traitement desdits désordres.

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