A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/73 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 36/40 (2006.01) A61K 36/44 (2006.01) A61K 36/708 (2006.01) A61K 38/20 (2006.01)
Patent
CA 2527052
An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
L'invention concerne un extrait de mûre chinoise (Rubus suavissimus) permettant d'inhiber l'angiogenèse, et deux fractions isolées. L'acide gallique est un des composés anti-angiogéniques dans un modèle d'angiogenèse humain in vitro. Des extraits aqueux d'autres plantes comprenant de l'acide gallique présentent une activité anti-angiogénique. De nombreux dérivés d'acide gallique permettent d'inhiber l'angiogenèse. L'extrait de mûre chinoise diminue également la croissance d'une tumeur pancréatique et la néovascularisation cornéenne des rats. Des extraits de grenade permettent d'inhiber l'angiogenèse dans des tissus graisseux. Des extraits de Rubus spp, et d'autres plantes à acide gallique, de l'acide gallique et ses dérivés sont utilisés pour traiter de nombreuses maladies associées à la néovascularisation, notamment la rétinopathie diabétique, le psoriasis, les tumeurs, l'obésité, le cancer, l'arthrite rhumatoïde, etc.
Greenway Frank L.
Liu Zhijun
Woltering Eugene A.
Board Of Supervisors Of Louisiana State University And Agricultu
Mcfadden Fincham
LandOfFree
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