Angiogenic compounds and uses thereof

Details Angiogenic compounds and uses thereof Angiogenic compounds and uses thereof

C - Chemistry, Metallurgy

07

J

C07J 31/00 (2006.01) A61K 31/575 (2006.01) A61K 38/18 (2006.01) C07J 9/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2508913

The invention provides sterol sulphate compounds according to formula (I) and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds. In said formula, R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group; X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3-; and least one of X, Y, or Z is OSO3-; provided that the compound does not have the precise structure of any of the structures listed in Tables I or II.

La présente invention concerne des composés stérol sulfates de la formule (1) et des compositions capables de promouvoir l'angiogenèse. L'invention se rapporte également à des procédés et à des utilisations desdits composés. Dans la formule précitée, R est un groupe alkyle linéaire ou ramifié, saturé ou insaturé, de 1 à 15 atomes de carbone ; X, Y et U sont choisis indendamment dans le groupe composé de H, OH et OSO¿3??-¿; et X et/ou Y et/ou Z est/sont OSO¿3??-¿; à condition que le composé ne possède pas la structure précise d'une quelconque des structures listées dans les tableaux I ou II.

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