Angiogenic lipid formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/075 (2006.01) A61K 31/08 (2006.01) A61K 31/23 (2006.01) A61K 31/365 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2220222

There is disclosed an aqueous formulation for vascularizing ischemic or grafted tissue, comprising an alk-1-enyl glycerol derivative having formula (I) wherein R is a straight or branched C1-24 saturated or unsaturated alkyl or a straight or branched C1-24 aryl and X and Y each is H or an saturated or unsaturated alkyl group having from 2 to 26 carbon atoms, or a monoglyceride having a C8-24 ether-linked saturated alkyl in an aqueous buffered pharmaceutical carrier.

L'invention porte sur une formulation aqueuse servant à vasculariser des tissus ischémiques ou greffés et comportant un dérivé du alc-1-ényle glycérol de formule (I) dans laquelle R est un alkyle C¿1-24? droit ou ramifié, saturé ou non ou un aryle C¿1-24? droit ou ramifié, et X et Y sont chacun H ou un groupe alkyle saturé ou non présentant de 2 à 26 atomes de carbone, ou un monoglycéride présentant un alkyle C¿8-24? à liaison éther dans un support pharmaceutique aqueux tamponné.

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