Angiogenic onchocerca volvulus proteins and uses thereof

Details Angiogenic onchocerca volvulus proteins and uses thereof Angiogenic onchocerca volvulus proteins and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/17 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2403985

The present invention provides a method for inducing angiogenesis in a tissue, by contacting the tissue with an amount of Ov-ASP effective to induce angiogenesis in the tissue. The present invention further provides a method for screening for an anti-Ov-ASP factor, by contacting a factor of interest with Ov-ASP, and assessing the ability of the factor to inhibit angiogenic activity of Ov-ASP. Additionaly, the present invention provides a method for inhibiting angiogenesis in a subject.

L'invention concerne une méthode permettant d'induire l'angiogenèse dans un tissu en mettant ledit tissu en contact avec un taux de Ov-ASP suffisant pour induire l'angiogenèse dans le tissu. L'invention concerne également une méthode permettant d'effectuer un criblage afin de rechercher un facteur anti-Ov-ASP, en mettant un facteur d'intérêt en contact avec Ov-ASP, et en évaluant la capacité dudit facteur à inhiber l'activité angiogénique de Ov-ASP. En outre, l'invention concerne une méthode permettant d'inhiber l'angiogenèse chez un sujet.

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