Angiogensis models using nestin-expressing stem cells to...

Details Angiogensis models using nestin-expressing stem cells to... Angiogensis models using nestin-expressing stem cells to...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2543966

The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.

L'invention concerne l'observation que l'expression de la nestine est un marqueur de la prolifération des cellules endothéliales. L'expression de la nestine est particulièrement utile comme marqueur de l'angiogenèse, particulièrement de l'angiogenèse liées à une tumeur. Plus spécifiquement, la nestine est un excellent marqueur endothélial des tumeurs du cerveau, telles que les gliomes, les hémangioblastomes, schwannomes, médulloblastomes et méningiomes. Par conséquent, l'invention concerne l'utilisation de ce marqueur en tant que base pour une activité angiogénique modèle.

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