Angiopoietin-like 2 as a biomarker of vascular endothelial...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) C07H 21/00 (2006.01) C07K 14/515 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2592372

A method for assessing a physiological state of a mammal. The method includes: obtaining from the mammal a biological sample; measuring the expression of angiopoietin-like 2 in the biological sample; and assessing the physiological state of the mammal by comparing the measured expression of the angiopoietin-like 2 to a predetermined normal expression level in normal subjects, wherein an increase in angiopoietin-like 2 level over the predetermined normal expression level indicates an abnormal physiological state.

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