Angiostatin fragments and method of use

Details Angiostatin fragments and method of use Angiostatin fragments and method of use

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291892

Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.

On décrit des fragments d'un inhibiteur de la prolifération cellulaire endothéliale ainsi qu'un procédé d'utilisation de ces fragments. L'inhibiteur de la prolifération endothéliale est une protéine dérivée du plasminogène, ou plus spécifiquement un fragment d'angiostatine. Les fragments d'angiostatine correspondent généralement à la structure kringle apparaîssant dans l'inhibiteur de prolifération cellulaire endothéliale. L'activité inhibitrice de la prolifération de cellules endothéliales de fragments constitue un moyen d'inhibition de l'angiogenèse des tumeurs et de traitement des maladies induites de façon angiogénique.

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