Angiotensin converting enzyme inhibitors

Details Angiotensin converting enzyme inhibitors Angiotensin converting enzyme inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/51 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/38 (2006.01) A61K 31/66 (2006.01) C07C 229/36 (2006.01) C07C 233/83 (2006.01) C07C 233/87 (2006.01) C07C 323/52 (2006.01) C07C 323/56 (2006.01) C07C 323/64 (2006.01) C07D 333/34 (2006.01) C07D 339/06 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2085993

2085993 9200276 PCTABS00010 There are disclosed compounds of formula (I): Z(CH2)nCHR1COOCHR2COOH, in which Z is -SR3, -COCHR4NHCOR5, (a) or -NHCHR7COOH; R4, R5, R6 and R7, which may be the same or different, are each phenyl or alkylphenyl C7-12; R1 is hydrogen, alkyl C1-6, NHR8 or (CH2)pR9; R2 is (CH2)mXR10, alkyl C1-6 optionally substituted by a saturated 5- or 6-membered carbocyclic or heterocyclic ring, alkylhalo C1-6, alkylcyano C1-6, or alkylphenyl C7-12, the phenyl being optionally substituted by NO2 or NH2; X is O, S(O)q, C=O or NR11, and R10 is alkyl C1-6, alkylhalo C1-6, alkoxy C1-6, alkoxy C1-6 substituted by halogen, alkanoyl C1-6, S(O)rR12, NR13R14, phenyl, alkylphenyl C7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring; n is an integer from 0 to 6; m and p, which may be the same or different, are each an integer from 1 to 6; R9 is hydrogen, SR15 or phenyl optionally substituted by OR16; R3 and R15, which may be the same or different, are each hydrogen or alkanoyl C1-6; R8 is hydrogen or COOR17; q and r, which may be the same or different, are each 0, 1 or 2, and R11, R12, R13, R14, R16 and R17, which may be the same or different, are each hydrogen or alkyl C1-6; and pharmaceutically acceptable salts thereof, with certain provisos. Processes for the preparation of the compounds, pharmaceutical compositions containing them and methods of treatment involving their use are also described.

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