C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/083 (2006.01) A23L 1/305 (2006.01) A61K 38/06 (2006.01) A61P 9/12 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2526891
It is intended to provide ACE inhibitory tripeptides which are not easily digested by digestive enzymes after being orally taken and thus have fewer tendencies to lose their ACE inhibitory activity in vivo. More specifically, 3 tripeptides having an ACE inhibitory activity and showing a hypotensive effect in an animal experiment are discovered from a thermolysin digestion product of sesame. These tripeptides respectively have amino acid sequences Leu-Ser-Ala, Val-Ile-Tyr and Leu-Val-Tyr and show an angiotensin converting enzyme inhibitory activity.
Cette invention a pour but de produire des tripeptides inhibiteurs de l'enzyme ACE qui ne sont pas facilement digérés par les enzymes digestives après avoir été ingérés et qui ont par conséquence moins tendance à perdre leur effet inhibiteur d'ACE in vivo. Plus spécifiquement, trois tripeptides ayant un effet inhibiteur de l'enzyme ACE et produisant un effet hypotenseur sur un modèle d'expérimentation animale ont été découverts à partir d'un produit du sésame obtenu par digestion par thermolysine. Ces tripeptides ont respectivement des séquences d'acides aminés Leu-Ser-Ala, Val-Ile-Tyr et Leu-Val-Tyr et produisent un effet inhibiteur de l'enzyme ACE.
Asami Sumio
Iino Taeko
Ogura Kyoichi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Suntory Holdings Limited
Suntory Limited
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