C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/675 (2006.01) A61P 9/12 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2723725
A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) -C(R1R2) (C(R3R4))0-1Y1R5, and 3) -C(R1R2)-O-Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)-O- and P(O)(OR6)-O-; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
L'invention porte sur un composé présentant une structure dans laquelle: R est par exemple (i), Y est sélectionné parmi: 1) R5, 2) -C(R1R2)(C(R3R4))0-1Y1R5, et 3) -C(R1R2)-O-Y1R5; R1, R2, R3 et R4 sont sélectionnés indépendamment parmi hydrogène et C1-4 alkyle; R5 est (ii); Y1 est sélectionné parmi C(O)-O- et P(O)(OR6)-O-; et R6 est hydrogène ou CH3, ou l'un de ses composés pharmacocompatibles. L'invention porte également sur l'utilisation desdits composés pour traiter l'hypertension.
Ali Amjad
Almirante Nicoletta
Biondi Stefano
Franklin Chris
Lo Michael Man-Chu
Merck Sharp & Dohme Corp.
Nicox S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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