Angiotensin ii receptor antagonists

Details Angiotensin ii receptor antagonists Angiotensin ii receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/4178 (2006.01)

Patent

CA 2604190

The compounds of the present invention are polymorphic crystalline forms of the compound 2-butyl-4-chloro-1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]- imidazole-5-carboxylic acid, which has the structure (I). Specifically, the compounds of the invention are selected from the group consisting of 2-butyl-4- chloro-1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid of Claim 3 selected from the group consisting of 2-butyl-4-chloro-1-[(2~- (1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid hydrochloride Form I, 2-butyl-4-chloro-1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4- yl)methyl]-imidazole-5-carboxylic acid hydrochloride Form II, 2-butyl-4-chloro- 1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid hydrochloride Form III, and 2-butyl-4-chloro-1-[(2~-(1-H-tetrazol-5- yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid monohydrate Form IV, 2- butyl-4-chloro-1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5- carboxylic acid monohydrate Form V, 2-butyl-4-chloro-1-[(2~-(1-H-tetrazol-5- yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid monohydrate Form VI, 2- butyl-4-chloro-1-[(2~-(1-H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5- carboxylic acid monohydrate Form VII, and 2-butyl-4-chloro-1-[(2~-(1-H- tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxylic acid monohydrate Form VIII.

Les composés de la présente invention sont des formes cristallines polymorphes de l'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique de structure (I). Plus particulièrement, les composés de l'invention sont choisis dans le groupe constitué par l'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique de la revendication 3 choisi parmi la forme I de l'hydrochlorure d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, la forme II de l'hydrochlorure d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, la forme III de l'hydrochlorure d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique et la forme IV du monohydrate d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, la forme V du monohydrate d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, la forme VI du monohydrate d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, la forme VII du monohydrate d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique, et la forme VIII du monohydrate d'acide 2-butyl-4-chloro-1-[(2'-(1-H-tétrazol-5-yl)biphényl-4-yl)méthyl]-imidazole-5-carboxylique.

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