Angiotensin ii receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 493/04 (2006.01) A61K 31/34 (2006.01) A61K 31/41 (2006.01) A61P 9/12 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2724919

A compound having the structure (I) wherein R is an angiotensin II receptor antagonist selected from the group consisting of (IIa)- (IIh); A is (Formula) wherein R1 and R2 are independently selected from the group consisting of hydrogen and C1-4 alkyl. Y is X0-Z wherein X0 is selected from the group consisting of: -O- , -O-CO-, -OCOO-, -OCONH- and -OSO2-; Z is a ni-tric oxide releasing moiety, or a pharmaceutically acceptable salt thereof.

La présente invention concerne un composé ayant la structure (I) dans laquelle R est un antagoniste des récepteurs de langiotensine II choisi dans le groupe constitué par (IIa)- (IIh) ; A est égal à (Formule), Rl et R2 étant indépendamment choisis dans le groupe constitué par lhydrogène et un groupe alkyle en C1-4 ; Y est X0-Z où X0 est choisi dans le groupe constitué par -O-, -O-CO-, -OCOO-, -OCONH- et -OSO2- ; Z est une fraction libérant de doxyde nitrique, ou un sel pharmaceutiquement acceptable de celui-ci.

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