Angiotensin peptide-carrier conjugates and uses thereof

Details Angiotensin peptide-carrier conjugates and uses thereof Angiotensin peptide-carrier conjugates and uses thereof

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 38/11 (2006.01) A61K 39/00 (2006.01) A61K 39/108 (2006.01) A61K 39/12 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 16/08 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2462857

The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of the resulting immunogen conjugates for the therapy and prophylaxis of conditions associated with the reninactivated angiotensin system.

L'invention concerne des conjugués de dérivés peptidiques de l'angiotensinogène d'hormones peptidiques mammifère, l'angiotensine I et l'angiotensine II, présentés dans un échafaudage répétitif par liaison des dérivés peptidiques à un porteur, plus spécifiquement une particule de type virus (VLP). L'invention concerne également des procédés de production de tels conjugués, ainsi que des utilisations immunothérapeutiques des conjugués immunogènes obtenus pour la thérapie et la prophylaxie d'états pathologiques associés au système angiotensine activé par la rénine.

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