Angiotropins of leukocytes and inflamed tissue and process...

C - Chemistry – Metallurgy – 12 – P

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167/114, 195/46,

C12P 21/00 (2006.01) A61K 35/14 (2006.01) C07K 14/515 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1188244

Abstract: New angiotropins of leukocytes and inflamed tissues are described having the following properties: a) bio- logical activities in vivo and in vitro: specific chemo- tropic action on blood vessels in vivo; induction of directional growth (chemotropism) of blood vessels along its concentration gradient; during vessel sprouting, tips of growing vessel capillaries have increased capillary permeability; induction of neovascularization of tissues by directional in-growth of blood vessels; substantial freedom of other biological effects; b) physico-chemical properties: electrophoretic migration in acrylamide matrices at a pH of 7.40 is anodic; soluble in aqueous media including in 20 % ethanol at a pH value of at least 4.0 to 10; constant temperature coefficient of solubility in ammonium sulfate solutions between -10°C and + 50°C; absorb reversibly in structure and biological activity on anion and cation exchangers, calcium phosphate gel and hydroxyapatite and can be subjected in native form to volume partition chromatography.

398616

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