C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/18 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/41 (2006.01) C07D 487/18 (2006.01) C07D 491/18 (2006.01) C07D 493/08 (2006.01) C07D 495/18 (2006.01)
Patent
CA 2337771
Anhydride modified cantharidin analogues useful in the treatment of certain forms of cancer also methods for the screening for anti-cancer activity of these analogues and/or their ability to sensitise cancer cells to cancer treatment. The modified cantharidin analogues have structure (I) or (II), wherein R1, R2, R3 and R4 are H, aryl or alkyl; X is O, N or S; Y is O, S, NH, NR; R is alkyl or aryl; A and B are H or CH3; W and Z are CHOH or C=O. These compounds inhibit protein phosphatase.
L'invention porte sur des anhydrides analogues de cantharidine modifiée utiles pour traiter certaines formes de cancer, et sur des procédés de criblage desdits analogues pour ce qui est de leurs activités anticancéreuses et/ou leur capacité de sensibilisation des cellules cancéreuses à des traitements anticancéreux. Les analogues de la cantharidine modifiée présentent la structure (I) ou (II) dans laquelle R¿1?, R¿2?, R¿3? et R¿4? sont H aryle ou alkyle; X est O, N ou S; Y est OS, NH, NR, R est aryle ou alkyle; A et B sont H ou CH¿3?; W et Z sont CHOH ou C=O. Ces composés inhibent la phosphatase protéique.
Ackland Stephen
Mccluskey Adam
Sakoff Jennette A.
Sim Alistair T. R.
Bull Housser & Tupper Llp
University Of Newcastle Research Associates Limited The
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