Anhydrous crystalline azido cytosine hemisulfate derivative

Details Anhydrous crystalline azido cytosine hemisulfate derivative Anhydrous crystalline azido cytosine hemisulfate derivative

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/7068 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2506532

The present invention relates to the hemisulfate salt of 1-[4(S)-azido- 2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)~-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating (I) and polymorphic crystalline forms thereof.

L'invention concerne un sel d'hémisulfate de 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxyméthyl)-1(R)-cyclopentyl]cytosine (Ia) à stabilité améliorée et à propriétés physiques facilitant la fabrication, le façonnage et la formulation de (I). L'invention concerne également les formes cristallines polymorphes de ces sels.

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