Anhydrous enhanced coupling

C - Chemistry – Metallurgy – 07 – K

Patent

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167/129, 530/3.0

C07K 17/00 (2006.01) A61K 39/385 (2006.01) C07K 1/107 (2006.01)

Patent

CA 1303292

-22- ANHYDROUS ENHANCED COUPLING Abstract An improvement in a method to conjugate a protein which must resist denaturation with a variable component using a carbodiimide condensing agent utilizes a polar aprotic solvent as the medium for condensation. This improvement results in shorter reaction times and improved coupling efficiency.

551178

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