Anhydrous enhanced coupling

Details Anhydrous enhanced coupling Anhydrous enhanced coupling

C - Chemistry, Metallurgy

07

K

167/129, 530/3.0

C07K 17/00 (2006.01) A61K 39/385 (2006.01) C07K 1/107 (2006.01)

Patent

CA 1303292

-22- ANHYDROUS ENHANCED COUPLING Abstract An improvement in a method to conjugate a protein which must resist denaturation with a variable component using a carbodiimide condensing agent utilizes a polar aprotic solvent as the medium for condensation. This improvement results in shorter reaction times and improved coupling efficiency.

551178

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