Aniline derivatives

Details Aniline derivatives Aniline derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/29 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) C07C 233/29 (2006.01) C07C 233/75 (2006.01) C07C 235/56 (2006.01) C07C 235/84 (2006.01) C07C 255/57 (2006.01) C07C 271/28 (2006.01) C07C 271/58 (2006.01) C07C 275/34 (2006.01) C07C 275/38 (2006.01) C07C 307/10 (2006.01) C07C 311/13 (2006.01) C07C 311/21 (2006.01) C07C 323/43 (2006.01) C07C 323/44 (2006.01) C07C 335/18 (2006.01) C07C 335/22 (2006.01) C07D 207/14 (2006.01) C07D 207/20 (2006.01) C07D 209/42 (2006.01) C07D 211/22 (2006.01) C07D 211

Patent

CA 2415551

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemmia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and/or treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

La présente invention concerne des composés représentés par la formule (I). Dans cette formule, U, Y, V, W, L, X, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿ et A?6¿ sont tels que définis dans la description et les revendications. L'invention concerne également des sels et/ou esters pharmaceutiquement admis de ces composés. Les composés de l'invention conviennent pour le traitement et/ou la prévention d'affections associées à la 2,3-oxydosqualène-lanostérol cyclase telles que l'hypercholestérolémie, l'hyperlipémie, l'artériosclérose, les affections vasculaires, les mycoses, les parasitoses, les calculs biliaires, les tumeurs et/ou les troubles hyperproliférants, et/ou le traitement et/ou la prévention des intolérances au glucose et le diabète.

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