Aniline derivatives or salts thereof and cytokine production...

Details Aniline derivatives or salts thereof and cytokine production... Aniline derivatives or salts thereof and cytokine production...

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 31/04 (2006.01) A61K 31/15 (2006.01) A61K 31/18 (2006.01) A61K 31/428 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 31/505 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 17/04 (2006.01) A61P 19/02 (2006.01) A61P 21/04 (2006.01) A61P 27/02 (2006.01) A61P 27/14 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (20

Patent

CA 2432713

The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: (see above formula) [wherein A is CO or SO2; Cy is an aryl group or a heterocyclic group; each of R1 and R2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a -B-Q group; R3 is a -M1-M2-R5 group; R4 is a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].

L'invention concerne des inhibiteurs de production de cytokine contenant en tant qu'ingrédient actif des dérivés d'aniline représentés par la formule générale (I) ou des sels de ceux-ci. Dans cette formule générale (I), A représente CO ou SO2, Cy représente aryle ou un groupe hétérocyclique, R<1 >et R<2> représentent indépendamment halogéno, cyano, nitro, alkyle éventuellement substitué, alcényle éventuellement substitué, alcynyle éventuellement substitué, cycloalkyle éventuellement substitué, cycloalcényle éventuellement substitué, aryle éventuellement substitué, un groupe hétérocyclique éventuellement substitué, amino éventuellement substitué, ou B-Q, R<3> représente M<1>-M<2>-R<5>, R<4> représente hydrogène ou alkyle éventuellement substitué, x représente un entier entre 0 et 5, y représente un entier entre 0 et 4, et z représente un entier en 0 et 1.

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