A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/36
A61K 49/04 (2006.01)
Patent
CA 1132901
ABSTRACT A process for the preparation of a sterile iniectable physiologically acceptable solution of an X-ray contrast agent and solutions of the X-ray contrast agent and a buffer Sterile, injectable, physiologically acceptable solutions of an X-ray contrast agent are prepared by autoclaving a solution-of a m-carboxamido-o-iodo-N-(.beta.- hydroxyalkyl)aniline X-ray contrast agent in the presence of a physiologically acceptable buffer system the pH of which decreases with increasing temperature. The presence of a temperature dependent buffer, preferably an amine, enables X-ray contrast agents to be sterilized by autoclaving without significant decomposition. Examples of the autoclaving processes are given and solutions for autoclaving containing a m- carboxamido-o-iodo-N-(.beta.-hydroxyalkyl)aniline X-ray contrast agent and a physiologically acceptable buffer system the pH of which decreases with increasing temperature are described and claimed.
331006
Kelly Michael J.
Rakli Fridtjov B.
Fetherstonhaugh & Co.
Nyegaard & Co. A/s
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