Animal and cell models for type ii diabetes and their use

Details Animal and cell models for type ii diabetes and their use Animal and cell models for type ii diabetes and their use

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2414652

A transgenic diabetes type II model laboratory animal is disclosed which comprises .beta.-cells expressing a dominant negative form (dnFGFR1c) of FGFR1c. Also disclosed is the use of the Ipf1/Pdx1 promoter for controlling expression of FGFR1c; .beta.-cells in wich the expression of PC1/3 is down- regulated or absent or which are competent to express a dominant negative form (dnFGFR1c) of FGFR1c; mature .beta.-cells incompetent to express Glut2 or in which the processing of proinsulin is substantially impaired; a method of preventing or treating type II diabetes.

La présente invention concerne un animal de laboratoire modèle de diabète de type II transgénique, ledit animal comprenant des cellules .beta. exprimant une forme négative dominante (dnFGFR1c) de FGFR1c. Cette invention concerne également l'utilisation du promoteur <i>Ipf1/Pdx1</i> pour réguler l'expression de FGFR1c ; des cellules .beta. dans lesquelles l'expression de PC1/3 est minimisée ou nulle, ou qui sont capables d'exprimer une forme négative dominante (dnFGFR1c) de FGFR1c ; des cellules .beta. matures qui ne sont pas capables d'exprimer Glut2 ou dans lesquelles le traitement de transformation de proinsuline en insuline est sensiblement perturbé ; un procédé de prévention ou de traitement du diabète de type II.

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