Animal derived cell with antigenic protein introduced therein

Details Animal derived cell with antigenic protein introduced therein Animal derived cell with antigenic protein introduced therein

C - Chemistry, Metallurgy

12

N

167/129, 167/163

C12N 5/08 (2006.01) A61K 9/127 (2006.01) A61K 9/50 (2006.01) A61K 35/18 (2006.01) A61K 38/16 (2006.01) A61K 47/42 (2006.01) G01N 33/543 (2006.01) G01N 33/555 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1327332

ABSTRACT This invention comprises animal derived cells, especially erythrocytes, which have been artificially modified (and referred to as enginerred erythrocytes or RBCs) so as to incorporate in their plasma membranes an antigen, CD4 protein derived from lymphocytes which will cause them to selectively seek out and fuse with other cells that are infected with a virus, especially the AIDS virus. These modified cells can be further altered so as to contain in their cytoplasm a cytotoxic agent which, after the cell has fused with a target cell, will result in the pooling of their respective cytoplasms and the death of both cells, with subsequent removal by the reticuloendothelial system. The invention also includes the production and use of similarly modified liposomes. The present invention can be used a treatment of Acquired Immune Deficiency Syndrome (AIDS), e.g. where the antigen on the modified cell is advantageously the CD4 antigen of animal lymphocytes and the target cell is an animal cell infected with the AIDS virus. This invention also relates to treatment of disease conditions, especially viral diseases and most notably AIDS, by injecting into a patient so afflicted a therapeutically effective amount of antigenically modified cells containing a cytotoxic substance. Such modified cells and liposomes can also be used as a basis for an in vitro diagnostic assay involving cells derived from the blood of patients suspected of having AIDS.

570526

Affiliated with

Also associated with

Rating

Animal derived cell with antigenic protein introduced therein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Animal derived cell with antigenic protein introduced therein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Animal derived cell with antigenic protein introduced therein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1272318