Animal model for evaluating vasomotor response in vivo

Details Animal model for evaluating vasomotor response in vivo Animal model for evaluating vasomotor response in vivo

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2740947

A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.

L'invention porte sur un procédé d'évaluation de l'effet d'un composé sur une réponse vasomotrice in vivo. Ce procédé comprend les étapes consistant à administrer ledit composé à un lapin et à mesurer le diamètre de la lumière de vaisseau d'une artère centrale de l'oreille dudit lapin par comparaison avec le diamètre de ligne de base de la lumière de vaisseau de ladite artère centrale de l'oreille dudit lapin, ledit diamètre de ligne de base étant mesuré avant l'administration dudit composé.

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