C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A01K 67/027 (2006.01) C12Q 1/70 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) C07K 14/16 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2284689
The present invention provides animals and methods for the evaluation of vaccines. In particular, the present invention provides humanized animal models for the evaluation of vaccines designed to confer immunity against human pathogens, including vaccines directed against the human immunodeficiency virus. The present invention further relates to HIV vaccines. In particular, the present invention provides attenuated replication-competent HIV vaccines and replication- defective HIV vaccines. In addition, the invention provides modified Leishmania cells expressing HIV proteins.
Cette invention a trait à un modèle animal aux fins d'une appréciation de vaccins ainsi qu'aux méthodes correspondantes. Elle porte notamment sur des modèles animaux humanisés destinés à permettre d'apprécier des vaccins conçus pour conférer une immunité contre des agents anthropopathogènes, y compris des vaccins contre le virus de l'immunodéficience humaine (VIH). L'invention, qui concerne, en outre, des vaccins contre le VIH, porte en particulier sur des vaccins contre le VIH atténués aptes et inaptes à la réplication. Elle fait, de surcroît, mention de cellules appartenant au genre Leishmania exprimant des protéines du VIH.
Chang Lung-Ji
Macrae & Co.
LandOfFree
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