Animal model for toxicology and dose prediction

Details Animal model for toxicology and dose prediction Animal model for toxicology and dose prediction

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12N 5/071 (2010.01) C12N 5/073 (2010.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2486548

The invention relates to the use of fetal tissues to generate a tissue model in a non-human animal. The tissue model comprises target tissues allowed to progress through development in vivo in a non-human host in order to obtain tissues having a mature phenotype that can be sued to assess toxicity and/or efficacy of an agent.

La présente invention se rapporte à l'utilisation de tissus foetaux afin de générer un modèle tissulaire chez un animal non humain. Le modèle tissulaire comprend des tissus cibles capables de progresser par leur développement in vivo dans un hôte non humain de manière à obtenir des tissus ayant un phénotype adulte que l'on peut utiliser pour évaluer la toxicité et/ou l'efficacité d'un agent.

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