C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 39/08 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2103693
ABSTRACT OF THE DISCLOSURE The present invention relates to a non-human chimeric mammal having characteristics of a functional human immune system and having functional human lymphocytes reconstituted in the mammal's lymphopoietic tissue, particularly the spleen. The invention also relates to a method of preparing a non-human chimeric mammal, having characteristics of a functional human immune system, by engraftment of human peripheral blood leukocytes into an immunocompromised mammal. Use of the chimeric mammal as a model of the human immune system is described.
Gallinger Steven
Hozumi Nobumichi
Roder John C.
Sandhu Jasbir S.
Shpitz Baruch
Bereskin & Parr
Mount Sinai Hospital Corporation
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