Animal models and methods for analysis of lipid metabolism...

Details Animal models and methods for analysis of lipid metabolism... Animal models and methods for analysis of lipid metabolism...

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 33/00 (2006.01) A01K 67/033 (2006.01) C07K 14/47 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2373628

Drosophila melanogaster and <i>C. elegans</i> that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living mematodes using fluorescently labeled fatty acid conjugates, such BODIPYTM fatty acid conjugates, are also described. Novel SREBP pathway nucleic acid and protein sequences are also described.

L'invention porte sur des Drosophila melanogaster et le <i>C. elegans</i> modifiés génétiquement pour exprimer ou mésexprimer des protéines intervenant dans le mécanisme de la protéine de fixation des éléments régulateurs des stérols (SREBP). Ces modèles d'animaux génétiquement modifiés présentent des phénotypes identifiables les rendant utiles dans des essais servant à l'étude: du métabolisme des lipides, d'autres gènes intervenant dans le métabolisme des lipides, et de composés capables de moduler le mécanisme du métabolisme des lipides. L'invention porte également sur des méthodes d'étude du métabolisme des lipides chez des nématodes vivants à l'aide de conjugués d'acide gras marqués par fluorescence tels que les conjugués BODIPY?TM¿, et sur de nouvelles séquences d'acides nucléiques et de protéines du mécanisme de la protéine SREBP.

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