Animal models and methods for sepsis

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2364017

Methods for selecting a candidate drug for treating sepsis are disclosed. The methods involve labeling a sepsis-causing pathogen with a reporter and monitoring the progress of infection by detecting levels of the reporter in animals treated with test compounds or drugs. The comparisons may be made between experimental and control animals, as well as within a single animal or group of animals. Also disclosed is a method for predicting an expected time of death of an experimental animal in a model system of sepsis using data generated in the initial part of the experiment.

L'invention concerne des méthodes de sélection d'un médicament candidat destiné à traiter la sepsie. Ces méthodes consiste à étiqueter un pathogène cause de sepsie avec un rapporteur et à surveiller l'évolution de l'infection en détectant les niveaux du rapporteur chez des animaux traités avec des composés ou médicament tests. On peut faire des comparaisons entre les animaux expérimentaux ou témoins, ainsi qu'auprès d'un seul animal ou dans un groupe d'animaux. L'invention concerne également une méthode de prévision du moment attendu de la mort d'un animal expérimental dans un système modèle de sepsie à l'aide des données recueillies dans la première partie de l'expérience.

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