Animals with reduced body fat and increased bone density

Details Animals with reduced body fat and increased bone density Animals with reduced body fat and increased bone density

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2558012

Methods for identifying animals as having reduced body fat and increased bone density are provided herein. Also provided herein are methods for generating animals having reduced body fat and increased bone density. The methods provided herein are based on the effect of TLR4, MD-2, and CD14 activity on body fat and bone density.

L'invention concerne des méthodes qui permettent d'identifier des animaux présentant une masse grasse réduite et une densité osseuse accrue et des méthodes qui permettent d'obtenir des animaux présentant une masse grasse réduite et une densité osseuse accrue. Ces méthodes sont basées sur l'effet de l'activité de TLR4, MD-2 et de CD14 sur la masse grasse et la densité osseuse.

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