Anion-exchange displacement chromatography process and...

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B01D 15/42 (2006.01) C07C 303/06 (2006.01) C07C 309/32 (2006.01) C07C 309/34 (2006.01) C07C 309/38 (2006.01) C07D 251/70 (2006.01)

Patent

CA 2630806

A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w = 2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An-, in which each An- is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

L'invention concerne un procédé de chromatographie de déplacement qui consiste à charger, sur une phase stationnaire comprenant une substance échangeuse d'anions, un mélange comprenant un ou plusieurs constituants à séparer, puis à déplacer au moins l'un de ces constituants hors de la phase stationnaire en appliquant à la phase stationnaire un mélange comprenant un composé de déplacement polyanionique polyaromatique de formule générale Cen (Ar)w. Dans cette formule, Cen représente une liaison ou un groupe central, Ar est un noyau aromatique, w est compris entre 2 et le nombre maximum de sites sur Cen, Ar est substitué par une pluralité de An, chaque An étant défini indépendamment comme sulfonate, carboxylate, phosphonate, phosphate ou sulfate, et Ar est en outre substitué par une pluralité de G, G étant défini indépendamment comme H, alkyle C1-C6, halogène, nitro, hydroxy ou alcoxy C1-C6. L'invention concerne également un groupe de composés de déplacement polyanioniques polyaromatiques utilisés dans ce procédé.

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