Anionic polymers as toxin binders and antibacterial agents

Details Anionic polymers as toxin binders and antibacterial agents Anionic polymers as toxin binders and antibacterial agents

A - Human Necessities

61

K

A61K 31/765 (2006.01) A61K 31/74 (2006.01) A61K 31/795 (2006.01) A61K 38/14 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2374108

The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.

La présente invention concerne une méthode d'inhibition d'une toxine chez un animal, tel qu'un humain, qui consiste à administrer audit animal une quantité thérapeutiquement efficace d'un polymère comprenant plusieurs groupes latéraux à fonction acide directement fixés au squelette du polymère par un groupe intercalaire. Le groupe intercalaire peut avoir une longueur comprise entre 0 et environ 20 atomes. La toxine est généralement une exotoxine sécrétée par un micro-organisme pathogène, tel qu'une bactérie.

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